pMEV2HA-cMYC

Human c-MYC Xpress Clone The MYC protooncogene encodes a multifunctional nuclear phosphoprotein of 65 kDa that can bind DNA and activate or repress transcription. Via this mechanism, MYC regulates expression of numerous target genes that control key cellular functions, including cell growth and cell cycle progression. MYC also has a critical role in DNA replication. Deregulated MYC expression resulting from various types of genetic alterations leads to constitutive MYC activity in a variety of cancers and promotes oncogenesis Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.OCT3/4, SOX2, c-Myc and KLF4 were initially used to generate induced pluripotent stem cells (iPSC) from mouse adult cells. Human somatic cells were later induced with the same set of genes, and with a different set of genes consisting OCT3/4, SOX2, NANOG and LIN28.Gene Name: Homo sapiens v-myc myelocytomatosis viral oncogene homolog (avian) (MYC); AKA: bHLHe39; c-Myc; MRTL. - 20 ug